The Growth & Increasing Cost of the Federal Prison System: Drivers and Potential Solutions

The federal prison population has been growing dramatically; its current population exceeds 218,000, with projections of continued growth for the foreseeable future. A wide array of actors -- Members of Congress, administration officials, a bipartisan cast of policy advocates, and researchers -- has concluded that this growth and its associated costs are unsustainable. The basis for this conclusion varies:Fiscal impact. Resources spent on the Bureau of Prisons (BOP) eclipse other budget priorities.Overcrowding risks. Overcrowded facilities can jeopardize the safety of inmates and staff and limit opportunities for effective programming that can reduce recidivism.Fairness/equity concerns. High levels of incarceration may have disproportionate impacts on certain subpopulations and communities.Inefficient resource allocation. Current research and recent evidence-based policy changes implemented in states raise questions about the cost-effectiveness of existing federal sentencing and corrections policies.The focus on this burgeoning population provides an opportunity to explore the drivers of population growth and costs and to develop options for stemming future growth that are consistent with public safety goals

Stemming the Tide: Strategies to Reduce the Growth and Cut the Cost of the Federal Prison System

The federal prison population has escalated from under 25,000 inmates in 1980 to over 219,000 today. This growth has come at great expense to taxpayers and other important fiscal priorities. As policymakers consider the array of options to stem the tide of inmates, our research concludes that a combination of strategies is the best way to make a real impact. In this report, we evaluate various policy options for cutting the size and costs of the burgeoning federal prison system

Evolution in coyotes (Canis latrans) in response to the megafaunal extinctions

Living coyotes modify their behavior in the presence of larger carnivores, such as wolves. However, little is known about the effects of competitor presence or absence on morphological change in coyotes or wolves over long periods of time. We examined the evolution of coyotes and wolves through time from the late Pleistocene, during which many large carnivorous species coexisted as predators and competitors, to the Recent; this allowed us to investigate evolutionary changes in these species in response to climate change and megafaunal extinctions at the end of the Pleistocene. We measured postcranial skeletal morphologies of wolves (Canis lupus) and coyotes (C. latrans) from Pleistocene-aged tar deposits, as well as early, mid, and recent Holocene populations of both. We found few morphological differences between Pleistocene and Holocene wolf populations. Conversely, we found many differences in coyotes: Pleistocene coyotes were larger and more robust than Holocene populations. However, within 1,000 y of the megafaunal extinctions, coyotes are morphologically indistinguishable from modern populations. We cannot attribute these differences directly to climate change because modern coyotes do not follow Bergmann’s rule, which states body size increases with decreasing temperature. Instead, we suggest that Pleistocene coyotes may have been larger and more robust in response to larger competitors and a larger-bodied prey base. Although we cannot separate competition from predator-prey interactions, this study indicates that the effects of biotic interactions can be detected in the fossil record

A Review of Age Friendly Virtual Assistive Technologies and their Effect on Daily Living for Carers and Dependent Adults

Many barriers exist in the lives of older adult’s, including health, transport, housing, isolation, disability and access to technology. The appropriate integration of technology within age-friendly communities continues to offer possible solutions to these barriers and challenges. Older adults and disabled people continue to be affected and marginalized due to lack of access to the digital world. Working collaboratively with planners, policy makers and developers, social and living spaces in the future will ensure that residents are equipped to live in an era that continues to be led by, and is dependent upon, access to technology. This review paper uniquely draws together the small volume of literature from the fields of gerontology, gerontechnology, human computer interaction (HCI), and disability. This paper examines the national and international age-friendly frameworks regarding older adults who are carers of dependent people with disabilities

Adoption and narrative in the digital age: how are social and digital media changing adoption?

This thesis explores some of the twenty-first century social networking challenges faced by all those involved in adoption. Written as an account of some fundamental changes taking place, where adoption and social networking have collided, this work examines some of the emerging tensions. Although much of the research is UKfocused, the changes within adoption in relation to social networking are more widely applicable. The inclusion of research material from other countries, including the US, is representative of these changes taking place within the field of adoption. Through the examination of popular media and adoption as narratives, an indication of social networking’s pervasiveness and the unforeseen changes in the provision of care of looked after children begin to emerge. In this new and still uncharted digital territory, all aspects of what it means to be adopted continue to evolve in the context of networked media cultures

Wireless Sensor Network for Monitoring of Historic Structures under Rehabilitation

The use of a wireless sensor network (WSN) to monitor an historic structure under rehabilitation is the focus of this research. To thoroughly investigate the issue, two main objectives are addressed: the development of a reliable WSN tailored for use in historic structures, and the implementation of the monitoring system in the field to test the feasibility of the WSN and its applicability for structural health monitoring (SHM). Three field studies are undertaken in this research. The Frankford Church, an historic wooden church which required foundation replacement, is the first field study. Sensors monitor tilt of the church’s walls throughout construction. During the construction process, the entire floor of the church is removed and the tree stump foundations are replaced by concrete masonry unit (CMU) blocks and steel pedestals. The tilt in the walls is correlated to the construction process. St. Paul Lutheran, an historic masonry church with timber-framed roof, constitutes the second field study. In this structure, the foundations along the exterior walls are underpinned and the floors are removed and replaced with a floating concrete slab. Detected movements are also correlated to the construction efforts. The Johanniskirche, an historic masonry church with moisture problems, is the final field study case. Real-time and past measured WSN climate data is used to determine the most appropriate solution for the humid climate and resulting condensation problems in this structure. From these results, a moisture migration risk analysis protocol is created for use with a WSN to address condensation issues. The results of the tilt monitoring indicate that the approach is realistic to monitor tilt in the walls of historic structures. For future research, it is recommended to implement motes with higher tilt sensitivity. Also, further development of energy saving algorithms and energy harvesting methods will improve the WSN’s performance. Climate monitoring results show it is feasible to monitor climate conditions of historic structures. The moisture migration protocol provides a basis for further improvement. Implementation of this tool will help predict condensation events and prevent future damage to the historic structure

Segregation of mtDNA Throughout Human Embryofetal Development: m.3243A > G as a Model System

Mitochondrial DNA (mtDNA) mutations cause a wide range of serious diseases with high transmission risk and maternal inheritance. Tissue heterogeneity of the heteroplasmy rate (“mutant load”) accounts for the wide phenotypic spectrum observed in carriers. Owing to the absence of therapy, couples at risk to transmit such disorders commonly ask for prenatal (PND) or preimplantation diagnosis (PGD). The lack of data regarding heteroplasmy distribution throughout intrauterine development, however, hampers the implementation of such procedures. We tracked the segregation of the m.3243A > G mutation (MT-TL1 gene) responsible for the MELAS syndrome in the developing embryo/fetus, using tissues and cells from eight carrier females, their 38 embryos and 12 fetuses. Mutant mtDNA segregation was found to be governed by random genetic drift, during oogenesis and somatic tissue development. The size of the bottleneck operating for m.3243A > G during oogenesis was shown to be individual-dependent. Comparison with data we achieved for the m.8993T > G mutation (MT-ATP6 gene), responsible for the NARP/Leigh syndrome, indicates that these mutations differentially influence mtDNA segregation during oogenesis, while their impact is similar in developing somatic tissues. These data have major consequences for PND and PGD procedures in mtDNA inherited disorders. Hum Mutat 32:116–125, 2011. © 2010 Wiley-Liss, Inc

Evolving growth hormone deficiency: proof of concept

IntroductionWe present the evolution of GHD in adolescent males with persistent growth failure, in whom the diagnosis was established after a second GH stimulation test (GST).MethodsWe performed a retrospective chart review of children who presented for short stature (height less < 2SD for mean/mid-parental height) and/or growth failure (sustained growth velocity < 0 SD) to pediatric endocrinology at Mount Sinai Kravis Children’s Hospital, New York and who had 2 GSTs. Data collected from electronic medical records were analyzed using SPSS v28.0ResultsOf 53 patients included, 42 were males. Average GH peak on initial GST was 15.48 ± 4.92 ng/ml, at 10.07 ± 2.65 years, mean height -1.68 ± 0.56SD(28% had <2SD), IGF-1 -1.00 ± 0.88SD. After 2.23 ± 1.22 years, at 12.04 ± 2.41years, height SDs decreased to -1.82 ± 0.63SD and IGF-1 was -1.08 ± 0.84SD. At repeat GST, average GH peak was 7.59 ± 2.12 ng/dL, with 36% ≤7 ng/dl and 32% in puberty. 12 males reached adult height of 0.08 ± 0.69 SD with a mean height gain of 1.83 ± 0.56SD(p<0.005), IGF-1 of -1.15 ± 0.81SD after 4.64 ± 1.4 years of GH.ConclusionWe offer evidence for Evolving Growth Hormone Deficiency (EGHD) through repeat GST in children with persistent growth slowdown, even with pubertal progression; emphasizing the need for careful longitudinal follow-up to make accurate diagnosis

Radiographs Reveal Exceptional Forelimb Strength in the Sabertooth Cat, Smilodon fatalis

Background: The sabertooth cat, Smilodon fatalis, was an enigmatic predator without a true living analog. Their elongate canine teeth were more vulnerable to fracture than those of modern felids, making it imperative for them to immobilize prey with their forelimbs when making a kill. As a result, their need for heavily muscled forelimbs likely exceeded that of modern felids and thus should be reflected in their skeletons. Previous studies on forelimb bones of S. fatalis found them to be relatively robust but did not quantify their ability to withstand loading. Methodology/Principal Findings: Using radiographs of the sabertooth cat, Smilodon fatalis, 28 extant felid species, and the larger, extinct American lion Panthera atrox, we measured cross-sectional properties of the humerus and femur to provide the first estimates of limb bone strength in bending and torsion. We found that the humeri of Smilodon were reinforced by cortical thickening to a greater degree than those observed in any living felid, or the much larger P. atrox. The femur of Smilodon also was thickened but not beyond the normal variation found in any other felid measured. Conclusions/Significance: Based on the cross-sectional properties of its humerus, we interpret that Smilodon was a powerful predator that differed from extant felids in its greater ability to subdue prey using the forelimbs. This enhanced forelimb strength was part of an adaptive complex driven by the need to minimize the struggles of prey in order to protec

Antarctic Relic Microbial Mat Community Revealed by Metagenomics and Metatranscriptomics

Buried upslope from the modern lakes in the McMurdo Dry Valleys of Antarctica are relict lake deposits embedded in valley walls. Within these relict deposits, ancient microbial mats, or paleomats, have been preserved under extremely arid and cold conditions since the receding of larger paleolakes thousands of years ago, and now serve as a sheltered niche for microbes in a highly challenging oligotrophic environment. To explore whether paleomats could be repositories for ancient lake cells or were later colonized by soil microbes, determine what types of metabolic pathways might be present, analyze potential gene expression, and explore whether the cells are in a vegetative or dormant state, we collected paleomat samples from ancient lake facies on the northern slopes of Lake Vanda in Wright Valley in December 2016. Using a gentle lysis technique optimized to preserve longer molecules, combined with a polyenzymatic treatment to maximize yields from different cell types, we isolated high-molecular weight DNA and RNA from ancient paleomat samples. Community composition analysis suggests that the paleomat community may retain a population of indigenous mat cells that may flourish once more favorable conditions are met. In addition to harboring a diverse microbial community, paleomats appear to host heterotrophs in surrounding soils utilizing the deposits as a carbon source. Whole genome long-read PacBio sequencing of native DNA and Illumina metagenomic sequencing of size-sorted DNA (>2,500 nt) indicated possible cell viability, with mat community composed of bacterial taxa. Metagenome assemblies identified genes with predicted roles in nitrogen cycling and complex carbohydrate degradation, and we identified key metabolic pathways such as stress response, DNA repair, and sporulation. Metatranscriptomic data revealed that the most abundant transcripts code for products involved in genetic information processing pathways, particularly translation, DNA replication, and DNA repair. Our results lend new insight into the functional ecology of paleomat deposits, with implications for our understanding of cell biology, Antarctic microbiology and biogeography, and the limits of life in extremely harsh environments